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University Of Minnesota Scientist Responds To Explosive Allegations Of Fraud In Alzheimer’s Research
JERRY HOLT ï 7/3/2006-----Portrait of Dr. Karen Hsiao Ashe.
JERRY HOLT/Star Tribune via Getty Images

UMN physician and neuroscientist Karen Ashe responded to a bombshell Science report published last week, which alleges that key images from one of the most cited research papers on Alzheimer’s disease this century might have been intentionally fabricated, throwing off years and hundreds of millions of dollars worth of taxpayer-funded research.

Matthew Schrag, a neuroscientist and physician at Vanderbilt University, stumbled upon the controversial study while investigating an experimental drug for Alzheimer’s. The 2006 study published in Nature by neuroscientist Sylvain Lesné of the University of Minnesota (UMN) “underpins a key element of the dominant yet controversial amyloid hypothesis of Alzheimer’s, which holds that [protein amyloid beta] Aβ clumps, known as plaques, in brain tissue are a primary cause of the devastating illness,” Science reported.

Ashe portrayed herself as a victim in the scandal, claiming that it was “devastating to discover that a co-worker may have misled me and the scientific community through the doctoring of images,” even though she should have been scrutinizing Lesné’s work.

“It is, however, additionally distressing to find that a major scientific journal has flagrantly misrepresented the implications of my work,” she said, adding that the article, which had input from numerous top Alzheimer’s experts, “erroneously conflated the two forms of Abeta.”

The Science report noted that the implication of the suspected fraudulent work means that hundreds of millions of dollars in taxpayer funds from the National Institutes of Health (NIH) might have been wasted and that the entire scientific field could have been searching in the wrong direction for the last 16 years for a cure for Alzheimer’s since thousands of studies were based on the study in question.

The authors “appeared to have composed figures by piecing together parts of photos from different experiments,” Elisabeth Bik, a molecular biologist and well-known forensic image consultant, told the publication. “The obtained experimental results might not have been the desired results, and that data might have been changed to … better fit a hypothesis.”

Schrag said that his investigation into Lesné’s and Ashe’s research contained images that appeared to be improperly duplicated or doctored.

Harvard University’s Dennis Selkoe, who was an advocate of the research that Lesné conducted, concluded in reviewing the images that there were “certainly at least 12 or 15 images where I would agree that there is no other explanation” other than the images were intentionally doctored, which he called “very worrisome.”

Selkoe added that there were other red flags with Lesné as some of his scientific comments “made no biochemical sense” to experts because “if it did, we’d all be using” similar methods.

After being confronted about the alleged fraudulent research, which Selkoe deemed was “highly egregious,” he acknowledged that there is now “precious little clearcut evidence that” the specific amyloid beta molecule at the center of the research, amyloid beta star 56 (Aβ*56) “exists, or if it exists, correlates in a reproducible fashion with features of Alzheimer’s—even in animal models.”

Numerous papers by Lesné have been flagged by the scientists leading the investigation for possible instances of fraud, which have led to corrections that have also been problematic.

Another scientist, cell biologist Denis Vivien, a senior scientist at Caen, alleged that in a separate study with Lesné, Lesné provided “dubious” looking research images that students could not replicate. Vivien cut off all contact with Lesné after the incident, saying, “We are never safe from a student who would like to deceive us and we must remain vigilant.”

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