President Donald Trump announced on Tuesday that popular medications will be offered at massively discounted prices — known as &#8220;most-favored-nation&#8221; prices — as pharmaceutical behemoth Pfizer commits to a $70 billion investment to manufacture drugs in the U.S.
<blockquote class="twitter-tweet">
President Trump: &#8220;All new medications introduced by Pfizer to the American market will be sold at the reduced, most favored nation cost.&#8221; <a href="https://t.co/S2CQxh7PKC">pic.twitter.com/S2CQxh7PKC</a>
— CSPAN (@cspan) <a href="https://twitter.com/cspan/status/1973055450980503972?ref_src=twsrc%5Etfw">September 30, 2025</a></blockquote>
A new website, called TrumpRX, will allow Americans to purchase drugs directly from the government rather than going through insurance. Virtually all drugs will be discounted on TrumpRX, the White House said.
Pfizer stepped up with a $70 billion investment, a shift toward making drugs in the U.S., which the Trump administration has addressed as a national security issue. 
The company is also offering all medications to Medicaid at most favored nations prices &#8212; which are prices comparable to or less than the cost of other nations&#8217; drug prices. Additionally, all new medications will be offered at most-favored-nation prices.
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Dermatitis medication, for example, will be discounted by 80% &#8212; and that refers to the net price, which is what consumers are actually paying. Meds for post-menopausal osteoporosis, which is extremely common, will be discounted by 85%. Migraine medication and rheumatoid arthritis drugs will be discounted by 50% and 40%, respectively.
<blockquote class="twitter-tweet">
PROMISES MADE, PROMISES KEPT: President Trump Delivers LOWER DRUG PRICES for Americans <a href="https://t.co/nA4tPrmcXt">pic.twitter.com/nA4tPrmcXt</a>
— Rapid Response 47 (@RapidResponse47) <a href="https://twitter.com/RapidResponse47/status/1973062430591692829?ref_src=twsrc%5Etfw">September 30, 2025</a></blockquote>
Health officials, including Food and Drug Administration (FDA) Commissioner Dr. Marty Makary, emphasized that research and development will not stop, but instead, will no longer be funded by only American citizens while the rest of the world benefits.
Makary, for instance, called the changes the &#8220;end of the great American ripoff.&#8221; He noted that drug price offsets will be directed to developed nations like France, Germany, and the U.K.
&#8220;Today marks the end of the great American ripoff, and it also marks the beginning of the end of a great American tragedy, something I’ve seen as a physician at the bedside — patients getting spun up into a financial rage &#8230; to try to get enough money to pay for a drug &#8230; a drug that&#8217;s five or ten times more expensive than the same drug in France or Germany or the U.K.,&#8221; he said.
<blockquote class="twitter-tweet" data-media-max-width="560">
.<a href="https://twitter.com/DrMakaryFDA?ref_src=twsrc%5Etfw">@DrMakaryFDA</a>: &#8220;Today marks the the beginning of the end of the great American rip off, and it also marks the beginning of the end of a great American tragedy; something I’ve seen as a physician at the bedside — patients getting spun up into a financial rage&#8230; to try to get… <a href="https://t.co/SD0iKsZR2B">pic.twitter.com/SD0iKsZR2B</a>
— Rapid Response 47 (@RapidResponse47) <a href="https://twitter.com/RapidResponse47/status/1973063636395373048?ref_src=twsrc%5Etfw">September 30, 2025</a></blockquote>
Dr. Mehmet Oz, who is the administrator of the Centers for Medicare &amp; Medicaid Services (CMS), echoed the sentiment, noting that the administration is &#8220;protecting medical advances for the future, while at the same time securing the drug prices Americans want, today.&#8221;
<blockquote class="twitter-tweet">
.<a href="https://twitter.com/DrOzCMS?ref_src=twsrc%5Etfw">@DrOzCMS</a>: &#8220;In July, President Trump demanded that manufacturers make a firm commitment to lower their prices “or else.” Last week, we made a major breakthrough. Protecting medical advances for the future, while at the same time securing the drug prices Americans want today.&#8221; <a href="https://t.co/56dvAt1OHi">pic.twitter.com/56dvAt1OHi</a>
— HHS.gov (@HHSGov) <a href="https://twitter.com/HHSGov/status/1973065918897881436?ref_src=twsrc%5Etfw">September 30, 2025</a></blockquote>
Trump announced his &#8220;most favored nation&#8221; pricing plans at the end of July, promising to end &#8220;global freeloading&#8221; by other developed nations. The president suggested he would use tariffs and all other &#8220;tools&#8221; available to make sure all companies provide Americans with most-favored-nation prices.
Related: <a href="https://www.dailywire.com/news/trump-signs-order-to-reduce-drug-prices-tells-rest-of-world-to-pay-up">Trump Signs Order To Reduce Drug Prices, Tells Rest Of World To Pay Up</a>

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‘End Of Great American Ripoff’: Trump Makes Major Drug Price Announcement

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‘End Of Great American Ripoff’: Trump Makes Major Drug Price Announcement