<p style="font-weight: 400;">Scientists at the University of Florida in Gainesville are developing a universal cancer vaccine designed to target cancer cells already forming in the body. The vaccine could be especially effective against some of the deadliest cancers, including pancreatic and ovarian cancer.</p>
<p style="font-weight: 400;">The problem in the past has been that because cancers tend to be specific to each person, a cancer vaccine would have to be tailored for that specific individual rather than a one-size-fits-all vaccine, and in the time spent to create a personal vaccine, the cancer could mutate.</p>
<p style="font-weight: 400;">“It can be months from the time you get a patient&#8217;s specimen to when they actually have a personalized therapy,” study senior author and pediatric oncologist Dr. Elias Sayour said, as Live Science <a href="https://www.livescience.com/health/cancer/universal-cancer-vaccine-heading-to-human-trials-could-be-useful-for-all-forms-of-cancer">reports</a>. “The idea that something could be available immediately, albeit in a nonspecific way … could be revolutionary for how we bridge therapy and how we manage patients.”</p>
<p style="font-weight: 400;">The experimental vaccine was discussed in the journal <a style="font-style: inherit; font-weight: inherit;" href="https://go.redirectingat.com/?id=92X1590019&amp;xcust=livescience_us_1632594187414033690&amp;xs=1&amp;url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41551-025-01380-1&amp;sref=https%3A%2F%2Fwww.livescience.com%2Fhealth%2Fcancer%2Funiversal-cancer-vaccine-heading-to-human-trials-could-be-useful-for-all-forms-of-cancer" data-analytics-id="inline-link" data-url="https://www.nature.com/articles/s41551-025-01380-1" data-hl-processed="skimlinks" data-placeholder-url="https://go.redirectingat.com/?id=92X1590019&amp;xcust=hawk-custom-tracking&amp;xs=1&amp;url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41551-025-01380-1&amp;sref=https%3A%2F%2Fwww.livescience.com%2Fhealth%2Fcancer%2Funiversal-cancer-vaccine-heading-to-human-trials-could-be-useful-for-all-forms-of-cancer" data-google-interstitial="false" data-merchant-name="nature.com" data-merchant-network="SkimLinks" data-mrf-recirculation="[Livescience] Article - Inline Link" data-mrf-link="https://go.redirectingat.com/?id=92X1590019&amp;xcust=livescience_us_4664427368791827916&amp;xs=1&amp;url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41551-025-01380-1&amp;sref=https%3A%2F%2Fwww.livescience.com%2Fhealth%2Fcancer%2Funiversal-cancer-vaccine-heading-to-human-trials-could-be-useful-for-all-forms-of-cancer" data-custom-tracking-id="1632594187414033690" data-hawk-tracked="hawklinks" data-label="Nature Biomedical Engineering">Nature Biomedical Engineering</a>; the abstract stated, “Our findings show that the resistance of tumors to immunotherapy is dictated by the absence of a damage response, which can be restored by boosting early type-I interferon responses to enable epitope spreading and self-amplifying responses in treatment-refractory tumors.”</p>
<p style="font-weight: 400;">The experimental vaccine is built on mRNA that triggers cells to produce new proteins, and hopes to strengthen the body to create more type-I interferons, which can locate cancerous tumors.</p>
<p style="font-weight: 400;">Sayour explained that cancer can impede interferon signals and block anti-cancer immune responses, so the experimental vaccine could catalyze an immune “reset.”</p>
<p style="font-weight: 400;">“I personally think this can be used for all forms of cancer,” Sayour stated. “I believe this is a universal paradigm that can be used to treat cancer,” adding that the vaccine could stop a relapse of the cancer after remission.</p>
<p style="font-weight: 400;">“This exciting and novel paper shows promising evidence that giving the immune system a short, targeted boost at just the right time can help previously unresponsive tumors respond to immunotherapy,&#8221; Diana Azzam, from the Center for Advancing Personalized Cancer Treatments at Florida International University, said. “This approach could be especially helpful for ‘cold’ tumors — types of cancer that usually don&#8217;t trigger a strong immune response, like pancreatic, ovarian, and some types of breast cancer.”</p>
<p style="font-weight: 400;">“Sayour and his colleagues have <a style="font-style: inherit; font-weight: inherit;" href="https://clinicaltrials.gov/study/NCT05660408" data-analytics-id="inline-link" data-url="https://clinicaltrials.gov/study/NCT05660408" data-hl-processed="none" data-mrf-recirculation="[Livescience] Article - Inline Link" data-mrf-link="https://clinicaltrials.gov/study/NCT05660408" data-custom-tracking-id="3743527965317849267" data-hawk-tracked="hawklinks" data-google-interstitial="false" data-label="launched a human trial testing a two-hit approach">launched a human trial testing a two-hit approach</a>: an off-the-shelf cancer vaccine followed by a personalized one,” Live Science noted. “This approach saves valuable time needed for personalized vaccinations and may induce rapid immunity that can be further seized upon by personalized therapy,&#8221; Sayour asserted.</p>

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Breakthrough Cancer Vaccine In The Works At University of Florida