President Donald Trump cracked up a crowd on Monday, when he poked fun at billionaire Mark Cuban during a major <a href="https://www.dailywire.com/news/trumprx-officially-launches-with-promise-to-dramatically-cut-drug-costs-for-americans">TrumpRx</a> announcement.
Trump&#8217;s administration has teamed up with Cuban and his company, Cost Plus Drugs, to bring Americans hundreds of drugs at much lower direct-to-consumer costs via TrumpRx. When the president was asked about working with Cuban, Trump quipped that it was a &#8220;big mistake&#8221; for the Dallas Mavericks minority owner to back Democrat Kamala Harris during the 2024 election.
&#8220;It&#8217;s pretty remarkable seeing you and Mark Cuban up there — the fact that Mark obviously endorsed Kamala Harris back in 2024,&#8221; a reporter said to Trump.
&#8220;Well, he made a mistake — it was a big mistake,&#8221; the president quickly responded, drawing laughter from the crowd.
Trump went on to say that both he and Cuban &#8220;love people&#8221; and &#8220;love our country.&#8221;
&#8220;He&#8217;s got a good company, he&#8217;s gonna get a lot of business with this, and I&#8217;m gonna get drugs out,&#8221; the president added.
<blockquote class="twitter-tweet" data-media-max-width="560">
🚨 LMFAO!! Funniest president ever 😂
REPORTER: It&#8217;s pretty remarkable seeing you and Mark Cuban up there, he endorsed Kamala Harris back in 2024
TRUMP: Well, he made a mistake!
CUBAN: 🤣🤣🤣
How the tables have turned! <a href="https://t.co/qLwOXvkKJb">pic.twitter.com/qLwOXvkKJb</a>
— Eric Daugherty (@EricLDaugh) <a href="https://twitter.com/EricLDaugh/status/2056490532105294241?ref_src=twsrc%5Etfw">May 18, 2026</a></blockquote>
For his part, Cuban praised Trump for making TrumpRx happen. &#8220;Other than you,&#8221; Cuban said to the president, &#8220;I&#8217;ve been the biggest proponent of TrumpRx.gov. And the reason for that is, Republicans want cheaper drugs, independents want cheaper drugs, Democrats want cheaper drugs — and together, I think we&#8217;re going to do something special.&#8221;
Americans can use TrumpRx.gov and find Cuban&#8217;s Cost Plus Drugs. Cuban said those drugs are currently only marked up 15%, a significantly lower cost than consumers typically pay. The entrepreneur added that teaming up with TrumpRx will add &#8220;volume&#8221; to Cost Plus Drugs, which in turn will make drug prices even lower going forward.
&#8220;This is a special announcement. This is a special partnership,&#8221; Cuban added. &#8220;We&#8217;re really excited to be part of this.&#8221;
<blockquote class="twitter-tweet" data-media-max-width="560">
🚨 WOW! Mark Cuban — who opposed Trump in 2024 — just gave a GLOWING ENDORSEMENT of 47 and TrumpRx
&#8220;This is a SPECIAL partnership. 559 [of 600] of the new drugs are OURS!&#8221;
&#8220;Together, we&#8217;re gonna make something special.&#8221;
&#8220;Other than you, I&#8217;ve been the biggest proponent of… <a href="https://t.co/gxv5kncdrm">pic.twitter.com/gxv5kncdrm</a>
— Eric Daugherty (@EricLDaugh) <a href="https://twitter.com/EricLDaugh/status/2056489288330592640?ref_src=twsrc%5Etfw">May 18, 2026</a></blockquote>
TrumpRx launched back in early February, with dozens of drugs listed at discounted prices for Americans. Now, the site offers more than 600 drugs at direct-to-consumer costs.
Some of the most regularly used medications added to TrumpRx include cholesterol medication Atorvastatin, diabetes drug Metformin, blood thinner Clopidogrel, and drugs often used for weight loss, like Ozempic, Wegovy, and Zepbound.
You can access <a href="https://trumprx.gov">TrumpRx here</a>.
Related: <a href="https://www.dailywire.com/news/trumprx-officially-launches-with-promise-to-dramatically-cut-drug-costs-for-americans">TrumpRx Officially Launches With Promise To Dramatically Cut Drug Costs For Americans</a>

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Trump And Mark Cuban’s White House Moment Takes Unexpected Turn

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Trump And Mark Cuban’s White House Moment Takes Unexpected Turn