Ralphie May, the larger-than-life comedian, has died at age 45 after suffering a heart attack.

While May had been doing standup comedy for years, his big break came in 2003, when he appeared on the NBC reality competition show, Last Comic Standing. Though May placed second, his career took off.

In the following years, May released multiple comedy specials, including Girth of a Nation, Austin-Tatious, and Too Big to Ignore.

In 2006, May married fellow comedian Lahna Turner. They had two children together — April and August. In 2015, Turner filed for divorce.

Those closest to May have offered statements regarding his passing.

Manager Judi Marmel told TMZ: "As his manager and his friend, I will miss his laugh, his generosity to fellow comedians, his trademark orneriness, and his enormous love of life. He left us entirely too soon — and we can only wonder where his comedy might have taken all of us. We send our love to his family, his fans, and all the comics who shared stages with him across the country."

Turner tweeted:

Other comedians have also expressed their sadness at his passing:

For the uninitiated, here’s a bit of Ralphie May (Warning: the following clip contains strong language):